Interleukin-33 and liver natural killer cells: A novel perspective on antitumor activity in liver fibrosis.
Yuki ImaokaMasahiro OhiraKouki ImaokaTomoaki BekkiRyosuke NakanoTakuya YanoYuka TanakaToshihiro NakayamaMiho AkabaneTetsuya TajimaShinichiro YokotaSheri M KramsOlivia M MartinezCarlos O EsquivelKazunari SasakiHideki OhdanPublished in: Hepatology research : the official journal of the Japan Society of Hepatology (2024)
Our study revealed a critical relationship between liver fibrosis and compromised tumor immunity, emphasizing the potential interference of IL-33 with NK cell function. These insights advocate for advanced immunostimulatory therapies targeting cytokines, such as IL-33, aiming to bolster the hepatic immune response against HCC in the context of liver fibrosis.