CSF chitinase proteins in amyotrophic lateral sclerosis.

Alexander Guy ThompsonElizabeth GrayAlexander BamptonDominika RaciborskaKevin TalbotMatthew C Kiernan

Published in: Journal of neurology, neurosurgery, and psychiatry (2019)

CSF chitinase proteins may have limited value as independent diagnostic and stratification biomarkers in ALS, but offer a window into non-autonomous mechanisms of motor neuronal loss in ALS, specifically in assessing response to therapies targeting neuroinflammatory pathways.

Keyphrases

amyotrophic lateral sclerosis
cancer therapy
cerebrospinal fluid
cerebral ischemia
drug delivery
brain injury
subarachnoid hemorrhage