Modulation of DNA Methylation and Gene Expression in Rodent Cortical Neuroplasticity Pathways Exerts Rapid Antidepressant-Like Effects.

Amanda J SalesIzaque S MacielAngélica C D R SuavinhaSâmia R L Joca

Published in: Molecular neurobiology (2020)

These findings suggest that acute inhibition of stress-induced DNA methylation promotes rapid and sustained antidepressant effects associated with increased BDNF-TrkB-mTOR signaling in the PFC.

Keyphrases

dna methylation
stress induced
gene expression
genome wide
liver failure
cell proliferation
intensive care unit
drug induced
aortic dissection
extracorporeal membrane oxygenation