Combined Vorinostat and Chloroquine Inhibit Sodium Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo.

Martin L Read Katie Brookes Ling Zha Selvambigai Manivannan Jana Kim Merve Kocbiyik Alice Fletcher Caroline M Gorvin George Firth Gilbert O Fruhwirth Juan Pablo Nicola Sissy Jhiang Matthew D Ringel Moray J Campbell Kavitha Sunassee Philip J Blower Kristien Boelaert Hannah R Nieto Vicki E Smith Christopher J McCabe

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

NIS internalisation is specifically druggable in vivo. Our data therefore provide new translatable potential for improving RAI therapy using FDA-approved drugs in patients with aggressive thyroid cancer.

Keyphrases

electronic health record
drug administration
human health
histone deacetylase
risk assessment
plasmodium falciparum
data analysis
mesenchymal stem cells
machine learning