Genetic and Epigenetic Associations with Pre-COPD Lung Function Trajectories.

David J Martino Shyamali C DharmageShuai LiSabrina IdroseJennifer L PerretAdrian LoweCaroline LodgeGayan BowatteYuben MoodleyPaul S ThomasGraeme ZoskyPhillip M HansbroJohn W HollowayCecile SvanseRosa FanerEugene H WaltersShaymali C Dharmage

Published in: American journal of respiratory and critical care medicine (2023)

High risk trajectories that progress to COPD exhibited genetic and epigenetic associations at epithelial and histocompatibility genes as well as accelerated epigenetic ageing.

Keyphrases

lung function
dna methylation
genome wide
chronic obstructive pulmonary disease
cystic fibrosis
air pollution
gene expression
depressive symptoms
copy number
genome wide analysis