Complement activating ABO anti-A IgM/IgG act synergistically to cause erythrophagocytosis: implications among minor ABO incompatible transfusions.

Priyanka PandeyWaseem Q AnaniTina PughJerome L GottschallGregory Andrew Denomme

Published in: Journal of translational medicine (2020)

High anti-A IgM/IgG titers act synergistically to cause significant monocyte erythrophagocytosis by activating complement C3, thus engaging both Fcγ- and CR1-receptors.

Keyphrases

signaling pathway
dendritic cells
endothelial cells
peripheral blood