First detection of a plasmid-encoded New-Delhi metallo-beta-lactamase-1 (NDM-1) producing Acinetobacter baumannii using whole genome sequencing, isolated in a clinical setting in Benin.
Carine Laurence YehouenouBert BogaertsKevin VannesteNancy H C RoosensSigrid C J De KeersmaeckerKathleen MarchalDissou AffolabiReza SoleimaniHector Rodriguez-VillalobosFrançoise Van BambekeOlivia DalleurAnne SimonPublished in: Annals of clinical microbiology and antimicrobials (2021)
The discovery of this extensively-drug resistant A. baumannii strain carrying blaNDM-1 in Benin is worrying, especially because of its high potential risk of horizontal gene transfer due to being integrated into a transposon located on a plasmid. Strict control and prevention measures should be taken, once NDM-1 positive A. baumannii has been identified to prevent transfer of this resistance gene to other Enterobacterales. Capacity building is required by governmental agencies to provide suitable antibiotic treatment options and strategies, in combination with strengthening laboratory services for detection and surveillance of this pathogen.
Keyphrases
- multidrug resistant
- drug resistant
- klebsiella pneumoniae
- acinetobacter baumannii
- gram negative
- escherichia coli
- loop mediated isothermal amplification
- genome wide
- copy number
- crispr cas
- healthcare
- real time pcr
- label free
- primary care
- public health
- genome wide identification
- pseudomonas aeruginosa
- gene expression
- candida albicans
- transcription factor
- human health