NLRP3 attenuates intraocular inflammation by inhibiting AIM2 mediated pyroptosis through the P-SIK1/SREBF1 pathway.

Jiayu MengNa LiXianyang LiuShengjun QiaoQian ZhouJun TanTing ZhangZhifang DongXiaopeng QiAize KijlstraLiming MaoPeizeng Yang Shengping Hou

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Our data show that NLRP3 inhibits AIM2 inflammasome mediated EAU by regulating the P-SIK1/SREBF1 pathway, highlighting the therapeutic potential of targeting Nlrp3. This article is protected by copyright. All rights reserved.

Keyphrases

nlrp inflammasome
oxidative stress
signaling pathway
electronic health record
big data
artificial intelligence
cataract surgery