scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases.
Samuel SchäferMartin SmelikOleg SysoevYelin ZhaoDesiré EklundSandra LiljaMika GustafssonHolger HeynAntonio JuliaIstván A KovácsJoseph LoscalzoSara MarsalHuan ZhangXinxiu LiDanuta GawelHui WangMikael BensonPublished in: Genome medicine (2024)
We propose a computational framework, scDrugPrio, for drug prioritisation based on scRNA-seq of IMID disease. Application to individual patients indicates scDrugPrio's potential for personalised network-based drug screening on cellulome-, genome-, and drugome-wide scales. For this purpose, we made scDrugPrio into an easy-to-use R package ( https://github.com/SDTC-CPMed/scDrugPrio ).