Platinum-based chemotherapy attenuates the effector response of CD8 T cells to concomitant PD-1 blockade.

Annapaola Mariniello Tahseen H Nasti Daniel Y Chang Masao Hashimoto Sakshi Malik Daniel McManus Judong Lee Donald J McGuire Maria Andrea Cardenas Pablo Umaña Valeria Nicolini Morie A Gertz Ananya Saha Zachary S Buchwald Haydn T Kissick Ehsan Ghorani Silvia Novello Dario Sangiolo Giorgio Vittorio Scagliotti Suresh R Ramalingam Rajesh M Valanparambil

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

In a translational context, we provide a proof-of-concept to consider optimizing the timing of chemo-immunotherapy strategies for improved CD8 T cell functions.

Keyphrases

locally advanced
photodynamic therapy
regulatory t cells
dendritic cells
rectal cancer
cancer therapy
type iii
radiation therapy
drug delivery
immune response
chemotherapy induced