Whole blood RNA-seq demonstrates an increased host immune response in individuals with cystic fibrosis who develop nontuberculous mycobacterial pulmonary disease.
Miguel Dario PrietoJiah JangAlessandro N FranciosiYossef Av-GayHoracio BachScott J TebbuttBradley S QuonPublished in: PloS one (2022)
In contrast to the non-cystic fibrosis population, the gene expression signature of patients with cystic fibrosis who develop NTM-PD is characterized by increased innate immune responses.
Keyphrases
- immune response
- rna seq
- gene expression
- cystic fibrosis
- single cell
- end stage renal disease
- ejection fraction
- toll like receptor
- chronic kidney disease
- dendritic cells
- newly diagnosed
- mycobacterium tuberculosis
- dna methylation
- magnetic resonance
- prognostic factors
- lung function
- computed tomography
- air pollution
- inflammatory response
- patient reported