MRI detection of the malignant transformation of stem cells through reporter gene expression driven by a tumor-specific promoter.

Jun SunJie HuangGuangcheng BaoHelin ZhengCui WangJie WeiYuanqiao FuJiawen QiuYifan LiaoJinhua Cai

Published in: Stem cell research & therapy (2021)

We developed a novel MRI model based on FTH1 reporter gene expression driven by the tumor-specific PEG3 promoter. This approach could be applied to sensitively detect the occurrence of MSC malignant transformation.

Keyphrases

gene expression
dna methylation
stem cells
contrast enhanced
magnetic resonance imaging
crispr cas
transcription factor
diffusion weighted imaging
risk assessment
drug delivery
cell therapy