A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice.

Susan BarendrechtAn SchreursStefanie GeisslerVictor SabanovVictoria IlseVera RieckmannRico EichentopfAnja KünemundBenjamin HietelSebastian WussowKatrin HoffmannKerstin Körber-FerlRavi PandeyGregory W CarterHans-Ulrich DemuthMax HolzerSteffen RoßnerStephan SchillingChristoph PreussDetlef BalschunHolger Cynis

Published in: Alzheimer's research & therapy (2023)

In summary, the multiple interactions observed between knocked-in human tau and the 5xFAD-driven progressing amyloidosis have important implications for future model development in AD.

Keyphrases

endothelial cells
mouse model
induced pluripotent stem cells
cerebrospinal fluid
subarachnoid hemorrhage
metabolic syndrome
skeletal muscle