miR-146b Protects the Perinatal Brain against Microglia-Induced Hypomyelination.

Cindy BokobzaPooja JoshiAnne-Laure SchangZsolt CsabaValérie FaivreAmélie MontanéAnne GallandAnouk Benmamar-BadelEmmanuelle BosherSophie LebonLeslie SchwendimannShyamala ManiPascal DournaudValerie BessonBobbi FleissPierre GressensJuliette Van Steenwinckel

Published in: Annals of neurology (2021)

These findings support that miRNA-146b-5p is a major regulator of microglia phenotype and could be targeted to reduce the incidence and the severity of perinatal brain injuries and their long-term consequences. ANN NEUROL 2021.

Keyphrases

resting state
white matter
inflammatory response
pregnant women
neuropathic pain
functional connectivity
risk factors
high glucose
diabetic rats
cerebral ischemia
transcription factor
oxidative stress
cancer therapy
multiple sclerosis
spinal cord
drug delivery
brain injury