Diastereoselective Synthesis of Highly Functionalized Proline Derivatives.

Anna N PhilippovaDaria V VorobyevaPavel S GribanovFedor M DolgushinSergey N Osipov

Published in: Molecules (Basel, Switzerland) (2022)

An efficient way to access highly functionalized proline derivatives was developed based on a Cu(I)-catalyzed reaction between CF 3 -substituted allenynes and tosylazide, which involved a cascade of [3 + 2]-cycloaddition/ketenimine and a rearrangement/Alder-ene cyclization to afford the new proline framework with a high diastereoselectivity.

Keyphrases

quantum dots
cystic fibrosis
molecularly imprinted
molecular docking
structure activity relationship
molecular dynamics simulations