Identification of novel therapeutic targets for blocking acantholysis in pemphigus.

Imke A K BurmesterSarah FlaswinkelClara-Sophie ThiesAnika KasprickMayumi KamaguchiValéria Bumiller-Bini HochShirin EmtenaniNick FeldmannKhalaf KridinEnno SchmidtNina van BeekDetlef ZillikensChristoph M HammersJennifer E HundtPardis-Sadat Tabatabaei-Panah

Published in: British journal of pharmacology (2020)

This unbiased screening revealed novel mechanisms by which PV autoantibodies induce blistering in keratinocytes and identified new treatment targets for this severe and potentially life-threatening skin disease.

Keyphrases

wound healing
systemic lupus erythematosus
early onset
replacement therapy
drug induced