Characterization of pathogen-inactivated COVID-19 convalescent plasma and responses in transfused patients.
Maja Weisser-RohacekNina KhannaAnemone HedstueckSarah Tschudin SutterSandra RoeschGregor StehleMihaela SavaNikolaus DeigendeschManuel BattegayLaura InfantiAndreas HolbroStefano BassettiHans ParggerHans H HirschKaroline LeuzingerLaurent KaiserDiem-Lan VuKatharina BaurNadine MassaroMichael Paul BuschGraham SimmonsMars StonePhilip L FelgnerRafael R de AssisSaahir KhanCheng-Ting TsaiPeter V RobinsonDavid SeftelJohannes IrschAnil BagriAndreas S BuserLaurence M CorashPublished in: Transfusion (2022)
PRT did not impact dCCP anti-virus neutralizing activity. Transfusion of unselected dCCP did not impact survival and had no adverse effects. Variable dCCP antibodies and post-transfusion antibody responses indicate the need for controlled trials using well-characterized dCCP with informative assays.