An Integrated Network Pharmacology and RNA-seq Approach for Exploring the Protective Effect of Andrographolide in Doxorubicin-Induced Cardiotoxicity.

Sa LiuJiaqin LiuNan SuShanshan WeiNing XieXiangyun LiSuifen XieJian LiuBikui ZhangWenqun LiShengyu Tan

Published in: Cardiovascular drugs and therapy (2024)

Andro could attenuate DIC through suppression of Tap1 and Timp1 and inhibition of NLRP3 inflammasome activation, serving as a promising cardioprotective drug.

Keyphrases

rna seq
nlrp inflammasome
single cell
drug induced
diabetic rats
drug delivery
emergency department
oxidative stress
stress induced