Combined effects of PNPLA3, TM6SF2 and HSD17B13 variants on severity of biopsy-proven non-alcoholic fatty liver disease.
Rafael PaternostroKatharina StauferStefan TraussniggAlbert-Friedrich StättermayerEmina HalilbasicOmar KeritamElias L MeyerJudith StiftFritz WrbaBence SiposAli CanbayMartin SchlattjanElmar AignerChristian DatzFelix StickelClemens SchafmayerJochen HampeStephan BuchGerhard PragerPetra MundaMattias MandorferPeter FerenciMichael TraunerPublished in: Hepatology international (2021)
In biopsy-proven NAFLD, PNPLA3 G/-, TM6SF2 T/- and HSD17B13 TA/- carriage are associated with severity of NAFLD. Incorporating these genetic risk factors into risk stratification models might improve their predictive accuracy for severity of NAFLD and/or advanced fibrosis on liver biopsy.