Dental pulp stem cell-derived exosomes alleviate cerebral ischaemia-reperfusion injury through suppressing inflammatory response.
Song LiLihua LuoYan HeRuohan LiYangfan XiangZhenjie XingYejian LiAbdullkhaleg Ali AlbashariXiangyan LiaoKeke ZhangLiang GaoQingsong YePublished in: Cell proliferation (2021)
DPSC-Exos can ameliorate I/R-induced cerebral injury in mice. Its anti-inflammatory mechanism might be related with the inhibition of the HMGB1/TLR4/MyD88/NF-κB pathway.
Keyphrases
- inflammatory response
- stem cells
- lps induced
- toll like receptor
- cerebral ischemia
- subarachnoid hemorrhage
- anti inflammatory
- signaling pathway
- lipopolysaccharide induced
- nuclear factor
- high glucose
- mesenchymal stem cells
- diabetic rats
- brain injury
- acute myocardial infarction
- immune response
- oxidative stress
- drug induced
- pi k akt
- adipose tissue
- blood brain barrier
- type diabetes
- heart failure
- metabolic syndrome
- cerebral blood flow