MicroRNA-mediated Krüppel-like factor 4 upregulation induces alternatively activated macrophage-associated marker and chemokine transcription in 4,4'-methylene diphenyl diisocyanate exposed macrophages.

Chen-Chung Lin Brandon F Law Justin M Hettick

Published in: Xenobiotica; the fate of foreign compounds in biological systems (2024)

4. In conclusion, hsa-miR-206-3p/hsa-miR-381-3p play a major role in regulation of MDI/MDI-GSH-induced M2 macrophage-associated markers and chemokines by targeting the KLF4 transcript, and KLF4-mediated regulation in macrophages.

Keyphrases

transcription factor
adipose tissue
high glucose
cell proliferation
signaling pathway
fluorescent probe
long non coding rna
single cell
stress induced