BKCa Channel Activation Attenuates the Pathophysiological Progression of Monocrotaline-Induced Pulmonary Arterial Hypertension in Wistar Rats.
Ana Paula FerrazFernando A C SearaEmanuelle F BaptistaThais S BarencoThais B B SottaniNatalia S C SouzaAiná E DomingosRaiana A Q BarbosaChristina M TakiyaMarcos T CoutoGabriel O ResendeAntonio C Campos de CarvalhoCristiano G PonteJose Hamilton Matheus NascimentoPublished in: Cardiovascular drugs and therapy (2020)
The use of a selective and potent opener to activate the BKCa channels promoted improvement of haemodynamic parameters and consequent prevention of RV maladaptive remodelling in rats with MCT-induced PAH.