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NK Cell Infiltrates and HLA Class I Expression in Primary HER2+ Breast Cancer Predict and Uncouple Pathological Response and Disease-free Survival.

Aura MuntasellFederico RojoSonia ServitjaCarlota Rubio-PerezMariona CaboDavid TamboreroMarcel Costa-GarcíaMaria Martinez-GarcíaSílvia MenéndezIvonne VazquezAna LluchAbel Gonzalez-PerezAna RoviraMiguel López-BotetJoan Albanell
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
This study identifies baseline TI-NK cells as an independent biomarker with great predictive value for pCR to anti-HER2 antibody-based treatment and points to the complementary value of tumor HLA-I status for defining patient prognosis independently of pCR.
Keyphrases
  • nk cells
  • free survival
  • case report
  • gene expression
  • binding protein
  • young adults
  • replacement therapy
  • smoking cessation