CD24 + LCN2 + liver progenitor cells in ductular reaction contributed to macrophage inflammatory responses in chronic liver injury.
Wei-Jian HuangBi-Jun QiuXiao-Shu QiCai-Yang ChenWen-Ming LiuShen-Ao ZhouMin DingFeng-Feng LuJie ZhaoDan TangXu ZhouGong-Bo FuZhen-Yu WangHong-Qian MaYu-Ling WuHong-Ping WuXiao-Song ChenWei-Feng YuHe-Xin YanPublished in: Cell & bioscience (2023)
LPCs constituted the expanding ductular reaction and contributed to macrophage-mediated inflammation in chronic liver damage. The current findings highlight the roles of LPCs from distinct origins and expose the possibility of targeting LPCs in the treatment of chronic hepatic diseases.