Prognostic value of von Willebrand factor levels in patients with metastatic melanoma treated by immune checkpoint inhibitors.
Julia-Christina StadlerLaura KellerChristian MessAlexander T BauerJulian KoettGlenn GeidelIsabel HeidrichSabine Vidal-Y-SyAntje AndreasCarlotta StramagliaMark SementsovWiebcke HaberstrohBenjamin DeitertInka Lilott HoehneRobin ReschkeThomas HaalckKlaus PantelChristoffer GebhardtStefan W SchneiderPublished in: Journal for immunotherapy of cancer (2023)
In this prospective cohort, coagulatory parameters such as ADAMTS13 activity and D-dimers are associated with OS but baseline vWF:Ag levels appeared as the only parameter associated with response and OS to ICI. This highlights a potential role of vWF as a biomarker to monitor ICI response of patients with malignant melanoma.
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