Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways.

Sabina RanjitNarasimha M MiddeNamita SinhaBenjamin J PattersMohammad A RahmanTheodore J CoryP S S RaoGolnoush Mirzahosseini

Published in: PloS one (2016)

These results suggest that of the five PAHs tested, BaP is the major contributor to the toxic effect of PAHs in monocytic cells, which is likely to occur through CYP and oxidative stress pathways.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
heavy metals
polycyclic aromatic hydrocarbons
signaling pathway
human health
dna damage
cell death
risk assessment
diabetic rats
health risk assessment
drinking water
heat shock