WWP2 Regulates Kidney Fibrosis and the Metabolic Reprogramming of Profibrotic Myofibroblasts.
Hui Mei ChenRan YouJing GuoWei ZhouGabriel ChewNithya DevapragashJui Zhi LohLoreto GesualdoYanwei LiYuteng JiangElisabeth Li Sa TanShuang ChenPaola PontrelliFrancesco PesceJacques BehmoarasAihua ZhangEnrico PetrettoPublished in: Journal of the American Society of Nephrology : JASN (2024)
WWP2 regulates the metabolic reprogramming of profibrotic myofibroblasts by a WWP2-PGC-1α axis, and WWP2 deficiency protects against kidney fibrosis in CKD.