Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI.
Tao-Tao TangBin WangZuo-Lin LiYi WenSong-Tao FengMin WuDan LiuJing-Yuan CaoQing YinDi YinYu-Qi FuYue-Ming GaoZhao-Ying DingJing-Yi QianQiu-Li WuLin-Li LvBi-Cheng LiuPublished in: Journal of the American Society of Nephrology : JASN (2021)
A red blood cell-derived extracellular vesicle platform targeted Kim-1 in acutely injured mouse kidney and delivered siRNAs for transcription factors P65 and Snai1, alleviating inflammation and fibrosis in the tubules.