A tumor suppressor Retinoblastoma1 is essential for embryonic development in the sea urchin.

Ana Fernandez-NicolasDerek XuMamiko Yajima

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2019)

Taken together, it appears that Vasa protein positively regulates Rb1 protein while Rb1 protein negatively regulates Vasa protein, balancing the act of these two antagonistic molecules in somatic cells. This mechanism may provide a fine control of cell proliferation and differentiation, which is essential for regulative embryonic development.

Keyphrases

cell proliferation
protein protein
amino acid
induced apoptosis
air pollution
cell cycle
dna methylation
copy number
endoplasmic reticulum stress