Recombinant T-cell epitope conjugation: A new approach for Dermatophagoides hypoallergen design.

Antônio Márcio Santana Fernandes Eduardo Santos da Silva Elisânia Fontes Silveira Emília Maria Medeiros de Andrade Belitardo Leonardo Freire Santiago Raphael Chagas Silva Vítor S Alves Deise Malta Carneiro Fatima Ferreira Alain Jacquet Luis Gustavo Carvalho Pacheco Neuza Maria Alcântara-Neves Carina da Silva Pinheiro

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2022)

rDer p 2231 has the potential to be used in AIT in patients co-sensitized with D. pteronyssinus major allergens, once it was able to reduce IgE production, inducing allergen-specific blocking antibodies, restoring and balancing Th1/Th2 immune responses, and inducing regulatory T-cells.

Keyphrases

regulatory t cells
immune response
end stage renal disease
dendritic cells
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
risk assessment
toll like receptor
patient reported outcomes
human health
patient reported