Epigenetic modulation inhibits epithelial-mesenchymal transition-driven fibrogenesis and enhances characteristics of chemically-derived hepatic progenitors.

Michael Adisasmita Hyomin K Lee Yohan An Myounghoi Kim Michael Girma Mamo Junho K Hur Dongho Choi Ji Hyun Shin Yun Kyung Jung

Published in: Annals of surgical treatment and research (2024)

These results highlight the capacity of 5-azacytidine to inhibit EMT-driven hepatic fibrosis and the significance of SOX9 on hepatic progenitor cell stemness properties.

Keyphrases

epithelial mesenchymal transition
stem cells
transforming growth factor
signaling pathway
transcription factor
liver fibrosis