Helicobacter pylori infection is an infectious disease and the empiric therapy paradigm should be changed.

Helicobacter pylori infection is an infectious disease. Given the alarmingly high antibiotic resistance in H. pylori , gastroenterologists should change the empiric H. pylori treatment paradigm to an antimicrobial susceptibility testing-guided precision treatment. Antimicrobial stewardship programs for H. pylori should be implemented locally, regionally, and nationally to monitor the antibiotic resistance pattern.