Systematic review of outcomes after total neoadjuvant therapy for locally advanced rectal cancer.
Alexandra M ZaborowskiAine StakelumD C WinterPublished in: The British journal of surgery (2019)
Total neoadjuvant therapy should be considered in patients with high-risk locally advanced rectal cancer owing to improved chemotherapy compliance and disease control. Further prospective studies are required to determine whether this approach translates into improved disease-related survival or increases the proportion of patients suitable for non-operative management.
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