Geospallins A⁻C: New Thiodiketopiperazines with Inhibitory Activity against Angiotensin-Converting Enzyme from a Deep-Sea-Derived Fungus Geosmithia pallida FS140.
Zhang-Hua SunJiangyong GuWei YeLiang-Xi WenQi-Bin LinSai-Ni LiYu-Chan ChenHao-Hua LiWei-Min ZhangPublished in: Marine drugs (2018)
Three new thiodiketopiperazines, geospallins A⁻C (1⁻3), together with nine known analogues (4⁻12), were isolated from the culture of the deep-sea sediment-derived fungus Geosmithia pallida FS140. Among them, geospallins A and B (1 and 2) represent rare examples of thiodiketopiperazines featuring an S-methyl group at C-10 and a tertiary hydroxyl group at C-11. Their structures were determined by high-resolution electrospray mass spectrometry (HRESIMS), spectroscopic analyses, and electronic circular dichroism (ECD) calculations. Their angiotensin-converting enzyme (ACE) inhibitory activity was reported, and geospallins A⁻C (1⁻3) showed inhibitory activity with IC50 values of 29⁻35 µM.
Keyphrases
- angiotensin converting enzyme
- mass spectrometry
- high resolution
- angiotensin ii
- molecular docking
- liquid chromatography
- molecular dynamics
- gas chromatography
- capillary electrophoresis
- molecular dynamics simulations
- high performance liquid chromatography
- heavy metals
- density functional theory
- tandem mass spectrometry
- risk assessment