Yta7, a chromatin segregase regulated by the cell cycle machinery.

Published in: Molecular & cellular oncology (2022)

We have recently revealed the existence of a cell cycle-regulated chromatin segregase, Yta7 (Yeast Tat-binding Analog 7), involved in chromosome replication. Phosphorylation of Yta7 by S-CDK (S-phase Cyclin-Dependent Kinase) regulates its function. These findings link the cell cycle to chromatin biology and suggest how chromatin-modifying enzymes become S phase-specific.

Keyphrases

cell cycle
transcription factor
dna damage
gene expression
cell proliferation
genome wide
dna binding
dna methylation
protein kinase
tyrosine kinase
single cell