Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5.

Eric D YoungSharon J ManleyThomas C BeadnellAlexander E ShearinKen SasakiRosalyn ZimmermanEvan KauffmanCarolyn J VivianAishwarya ParasuramTomoo IwakumaPaul M GrandgenettMichael A HollingsworthMaura O'NeilDanny R Welch

Published in: British journal of cancer (2020)

Metastasis suppression by ITIH5 may be mediated by an intracellular mechanism. In human PDAC, loss of ITIH5 may be an early event and ITIH5-low PDAC cells in primary tumours may be selected for liver metastasis. Further defining the ITIH5-mediated pathway in PDAC could establish future therapeutic exploitation of this biology and reduce morbidity and mortality associated with PDAC metastasis.

Keyphrases

induced apoptosis
endothelial cells
cell cycle arrest
induced pluripotent stem cells
endoplasmic reticulum stress
signaling pathway
cell death
oxidative stress