Automated apparent diffusion coefficient analysis for genotype prediction in lower grade glioma: association with the T2-FLAIR mismatch sign.
Eric AliottaSunil W DuttaXue FengNicholas J TustisonPrem P BatchalaDavid SchiffM Beatriz LopesRajan JainT Jason DruzgalSugoto MukherjeeSohil H PatelPublished in: Journal of neuro-oncology (2020)
Tumor subregions with high ADC were a robust indicator of IDHmut-Noncodel LGG, with VADC>1.5 achieving > 90% classification specificity in both internal and validation cohorts. VADC>1.5 exhibited strong concordance with the T2-FLAIR mismatch sign and the combination of both parameters improved sensitivity in detecting IDHmut-Noncodel LGG.