Outcomes in pregnancies with a confined placental mosaicism and implications for prenatal screening using cell-free DNA.
Francesca Romana GratiJose Carlos P FerreiraPeter BennClaudia IzziFederica VerdiElena VercellottiCristina DalpiazPatrizia D'AjelloElisa FilippiNicola VolpeFrancesca MalvestitiFederico MaggiGiuseppe SimoniTiziana FruscaGaetana CirelliGabriella BracalenteAntonino Lo ReDaniela SuricoTullio GhiFederico PrefumoPublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2019)
Excluding T16, the incidence of adverse pregnancy outcomes for pregnancies carrying a CPM is low. RATs can also be identified through genome-wide cell-free DNA screening. Because most of these will be attributable to CPMs, we conclude that this screening is of minimal benefit.