PI3k/AKT signaling pathway: Erythropoiesis and beyond.
Mahjoobeh JafariElham GhadamiTahereh DadkhahHaleh Akhavan NiakiPublished in: Journal of cellular physiology (2018)
Erythropoiesis is a multi-step process that involves the differentiation of hematopoietic stem cells into mature red blood cells (RBCs). This process is regulated by several signaling pathways, transcription factors and microRNAs (miRNAs). Many studies have shown that dysregulation of this process can lead to hematologic disorders. PI3K/AKT is one of the most important pathways that control many cellular processes including, cell division, autophagy, survival, and differentiation. In this review, we focus on the role of PI3K/AKT pathway in erythropoiesis and discuss the function of some of the most important genes, transcription factors, and miRNAs that regulate different stages of erythropoiesis which play roles in differentiation and maturation of RBCs, prevention of apoptosis, and autophagy induction. Understanding the role of the PI3K pathway in erythropoiesis may provide new insights into diagnosing erythrocyte disorders.
Keyphrases
- pi k akt
- signaling pathway
- cell cycle arrest
- transcription factor
- stem cells
- induced apoptosis
- epithelial mesenchymal transition
- red blood cell
- cell death
- endoplasmic reticulum stress
- cell proliferation
- oxidative stress
- cell therapy
- genome wide identification
- single cell
- bone marrow
- mesenchymal stem cells
- case control
- genome wide analysis