Remodeling adipose tissue through in silico modulation of fat storage for the prevention of type 2 diabetes.

Thierry ChénardFrédéric GuénardMarie-Claude VohlAndré CarpentierAndré TchernofRafael J Najmanovich

Published in: BMC systems biology (2017)

We generated a highly curated metabolic network of the human adipose tissue and used it to identify potential targets for adipose tissue metabolic dysfunction leading to the development of type 2 diabetes.

Keyphrases

adipose tissue
insulin resistance
type diabetes
high fat diet
endothelial cells
cardiovascular disease
glycemic control
induced pluripotent stem cells
metabolic syndrome
skeletal muscle
weight loss