Protective Effects of Sodium Para-Aminosalicylic Acid on Lead and Cadmium Co-Exposure in SH-SY5Y Cells.

Jian-Chao PengYue DengHan-Xiao SongYuan-Yuan FangCui-Liu GanJun-Jie LinJing-Jing LuoXiao-Wei ZhengMichael AschnerYue-Ming Jiang

Published in: Brain sciences (2023)

Combined exposure to Pb-Cd induced oxidative stress and cytotoxicity in SH-SY5Y cells. PAS-Na displayed antagonistic effects on neurodegenerative changes induced by combined Pb-Cd exposure; hence, it may afford a novel treatment modality for exposure to these metals.

Keyphrases

induced apoptosis
heavy metals
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
health risk assessment
cell death
oxidative stress
cell proliferation