Lung Dual-Energy CT Perfusion Blood Volume as a Marker of Severity in Chronic Thromboembolic Pulmonary Hypertension.
Salim Aymeric Si-MohamedLéa ZumbihlSégolène TurquierSara BoccaliniJean-Francois MornexPhilippe DouekVincent CottinLoic BousselPublished in: Diagnostics (Basel, Switzerland) (2023)
In chronic thromboembolic pulmonary hypertension (CTEPH), assessment of severity requires right heart catheterization (RHC) through cardiac index (CI). Previous studies have shown that dual-energy CT allows a quantitative assessment of the lung perfusion blood volume (PBV). Therefore, the objective was to evaluate the quantitative PBV as a marker of severity in CTEPH. In the present study, thirty-three patients with CTEPH (22 women, 68.2 ± 14.8 years) were included from May 2017 to September 2021. Mean quantitative PBV was 7.6% ± 3.1 and correlated with CI (r = 0.519, p = 0.002). Mean qualitative PBV was 41.1 ± 13.4 and did not correlate with CI. Quantitative PBV AUC values were 0.795 (95% CI: 0.637-0.953, p = 0.013) for a CI ≥ 2 L/min/m 2 and 0.752 (95% CI: 0.575-0.929, p = 0.020) for a CI ≥ 2.5 L/min/m 2 . In conclusion, quantitative lung PBV outperformed qualitative PBV for its correlation with the cardiac index and may be used as a non-invasive marker of severity in CTPEH patients.
Keyphrases
- dual energy
- computed tomography
- contrast enhanced
- pulmonary hypertension
- image quality
- high resolution
- left ventricular
- magnetic resonance imaging
- atrial fibrillation
- end stage renal disease
- newly diagnosed
- ejection fraction
- systematic review
- heart failure
- pulmonary artery
- chronic kidney disease
- magnetic resonance
- mass spectrometry
- prognostic factors
- metabolic syndrome
- patient reported outcomes
- polycystic ovary syndrome
- coronary artery
- adipose tissue
- pregnancy outcomes