Cancer in multi-lineage mosaic RASopathies due to pathogenic variants in HRAS or KRAS: a systematic review and meta-analysis.

Jonas Windrich Gina M Ney Philip S Rosenberg Jung Kim Martin Zenker Douglas R Stewart Christian Peter Kratz

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

This is the first investigation of cancer risk in KRAS or HRAS PV-positive mosaic RASopathies to date. The high incidence and SIR values found highlight the need for rigorous rhabdomyosarcoma surveillance in young children and skin cancer surveillance in adults with this high-risk condition.

Keyphrases

skin cancer
public health
wild type
papillary thyroid
risk factors
squamous cell
copy number
single cell
squamous cell carcinoma