SATB1-mediated chromatin landscape in T cells.
Tomas ZelenkaCharalampos G SpilianakisPublished in: Nucleus (Austin, Tex.) (2021)
The regulatory circuits that define developmental decisions of thymocytes are still incompletely resolved. SATB1 protein is predominantly expressed at the CD4+CD8+cell stage exerting its broad transcription regulation potential with both activatory and repressive roles. A series of post-translational modifications and the presence of potential SATB1 protein isoforms indicate the complexity of its regulatory potential. The most apparent mechanism of its involvement in gene expression regulation is via the orchestration of long-range chromatin loops between genes and their regulatory elements. Multiple SATB1 perturbations in mice uncovered a link to autoimmune diseases while clinical investigations on cancer research uncovered that SATB1 has a promoting role in several types of cancer and can be used as a prognostic biomarker. SATB1 is a multivalent tissue-specific factor with a broad and yet undetermined regulatory potential. Future investigations on this protein could further uncover T cell-specific regulatory pathways and link them to (patho)physiology.
Keyphrases
- transcription factor
- gene expression
- genome wide
- papillary thyroid
- protein protein
- human health
- single cell
- squamous cell
- squamous cell carcinoma
- amino acid
- small molecule
- genome wide identification
- skeletal muscle
- metabolic syndrome
- mesenchymal stem cells
- adipose tissue
- insulin resistance
- oxidative stress
- bone marrow
- current status
- young adults
- african american
- lymph node metastasis