Gene expression and ultra-structural evidence for metabolic derangement in the primary mitral regurgitation heart.

Mariame Selma Kane Juan Xavier Masjoan Juncos Shajer Manzoor Maximiliano Grenett Joo-Yeun Oh Betty Pat Mustafa I Ahmed Clifton Lewis James E Davies Thomas S Denney Jonathan E McConathy Louis J Dell'Italia

Published in: European heart journal open (2024)

The PMR heart has a global ultra-structural and metabolic gene expression pattern of decreased glucose uptake along with increased glycogen and LDs. Further studies must determine whether this presentation is an adaptation or maladaptation in the PMR heart in the clinical evaluation of PMR.

Keyphrases

gene expression
heart failure
dna methylation
atrial fibrillation
high resolution
type diabetes
metabolic syndrome
case control