Effect of CYP2C19, UGT1A8, and UGT2B7 on valproic acid clearance in children with epilepsy: a population pharmacokinetic model.

Shenghui MeiWeixing FengLeting ZhuXingang LiYazhen YuWeili YangBaoqin GaoXiaojuan WuFang FangZhigang Zhao

Published in: European journal of clinical pharmacology (2018)

TDD, BSA, and genotype might affect VPA clearance in children. The popPK models may be useful for dosing adjustment in children on VPA therapy.

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