Biomarkers of the L-Arginine/Dimethylarginine/Nitric Oxide Pathway in People with Chronic Airflow Obstruction and Obstructive Sleep Apnoea.

Juliane HannemannElin H ThorarinnsdottirAndre F S Amaral Edzard SchwedhelmLena Schmidt-HuttenHeike StangBryndis BenediktsdottirIngibjörg GunnarsdottirThórarinn GislasonRainer H Böger

Published in: Journal of clinical medicine (2023)

The plasma concentrations of ADMA and SDMA are elevated in COPD patients with concomitant intermittent hypoxaemia. This may account for impaired pulmonary NO production, enhanced pulmonary vasoconstriction, and disease progression.

Keyphrases

nitric oxide
pulmonary hypertension
chronic obstructive pulmonary disease
nitric oxide synthase
hydrogen peroxide
physical activity
lung function
sleep quality
positive airway pressure
obstructive sleep apnea
cystic fibrosis
drug induced