The Inositol Trisphosphate Receptor (IP 3 R) is Dispensable for Rotavirus-induced Ca 2+ Signaling and Replication but Critical for Paracrine Ca 2+ Signals that Prime Uninfected Cells for Rapid Virus Spread.

Jacob L PerryFrancesca J ScribanoJohn T GebertKristen A EngevikJenna M EllisJoseph M Hyser

Published in: bioRxiv : the preprint server for biology (2023)

signals from the ICWs may prime nearby uninfected cells to better support virus replication upon eventual infection. This "pre-emptive priming" of uninfected cells by exploiting host intercellular pathways in the vicinity of virus-infected cells represents a novel mechanism for viral reprogramming of the host to gain a replication advantage.

Keyphrases

induced apoptosis
cell cycle arrest
hiv infected
endoplasmic reticulum stress
sars cov
oxidative stress
cell proliferation
protein kinase
drug induced