MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice.

Xiao-Lan WangCheng MiaoYanfang SuChun ZhangXianfang Meng

Published in: The international journal of neuropsychopharmacology (2023)

Our results suggest an important role of neuronal MAD2B in the pathogenesis of depression via the miR-29b-3p/GRM4 signaling pathway. MAD2B could be a potential therapeutic target for depressive disorders.

Keyphrases

stress induced
signaling pathway
depressive symptoms
sleep quality
high glucose
diabetic rats
bipolar disorder
pi k akt
high fat diet induced
metabolic syndrome
human health
type diabetes
risk assessment
induced apoptosis
blood brain barrier