A Biodegradable Nanosuspension Locally Used for Inhibiting Postoperative Recurrence and Brain Metastasis of Breast Cancer.
Min QianGuangwei JiangWei GuoRongqin HuangPublished in: Nano letters (2024)
Addressing the urgent need to prevent breast cancer postoperative recurrence and brain metastasis, Fe-metal organic framework (MOF)-coated hollow mesoporous organosilica nanoparticles (HMON) with tumor microenvironment dual-responsive degradability were prepared to encapsulate doxorubicin (DOX), formulating a tissue-adhesive nanosuspension for perioperative topical medication. This nanosuspension can not only retain the sustainably released drug in the postoperative residual tumor sites but also enhance the intracellular oxidative stress of tumors for remarkable tumor ferroptosis. Interestingly, the nanosuspension can act as an immune amplifier, which could not only stimulate DC cells to secrete chemokines for T cell recruitment but also elevate antigen exposure to facilitate the antigen presentation in lymph nodes. Thus, this nanosuspension could significantly activate antitumor immune responses in both in situ tumors and metastatic encephaloma for enhanced immunotherapy. In conjunction with the clinical PD-1 antibody, the locally administered nanosuspension could achieve an advanced therapeutic outcome for inhibiting postoperative recurrence and metastasis.
Keyphrases
- metal organic framework
- patients undergoing
- oxidative stress
- lymph node
- induced apoptosis
- immune response
- signaling pathway
- drug delivery
- free survival
- small cell lung cancer
- squamous cell carcinoma
- cell death
- cancer therapy
- white matter
- dendritic cells
- cardiac surgery
- cell cycle arrest
- dna damage
- inflammatory response
- early stage
- mass spectrometry
- toll like receptor
- cell proliferation
- acute kidney injury
- young adults
- liquid chromatography
- drug induced
- molecularly imprinted
- cerebral ischemia
- heat stress
- heat shock protein
- breast cancer risk
- diabetic rats